Lakshminarayan Reddy Teegala, Ph.D.
Assistant Professor聽
Bone Remodeling & Inflammation Research Laboratory
Research Interest
Bone is a dynamic tissue that continuously undergoes remodeling, involving the removal of mature bone tissue by osteoclasts and the formation of new bone tissue by osteoblasts. An imbalance in remodeling process is due to excessive osteoclastic bone resorption or reduced osteoblastic bone formation, or both, and is the underlying cause for bone-related disorders such as osteoporosis, osteoarthritis, rheumatoid arthritis, etc. Our research aims to elucidate the molecular mechanisms driving bone remodeling, with a focus on inflammatory signaling in osteoclasts and osteoblasts, as well as their interactions with immune cells to develop new approaches for treating bone and its associated disorders.
Education & Training
- 2015: Ph.D. Biological Sciences, Indian Institute of Chemical Technology, Telangana, India.
- 2008: M.S. Chemistry, Osmania University, Telangana, India.
- 2004: B.Ed. Education, Kakatiya University, Telangana, India.
- 2003: B.S. Chemistry, Zoology, Microbiology, Osmania University, Telangana, India.
Professional Experience
- 2024-
- Instructor, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH聽聽
- Mentor: Sailaja Paruchuri, Ph.D.
- 2021-2024
- Postdoctoral Fellow, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH. 聽聽聽聽聽聽聽聽聽聽
- Advisor: Sailaja Paruchuri, Ph.D.
- 2019-2021
- Sr. Postdoctoral Research Associate, Department of Chemistry, University of Akron, Akron OH. 聽聽聽
- Advisor: Sailaja Paruchuri, Ph.D.
- 2016-2019
- Postdoctoral Research Associate, Department of Chemistry, University of Akron, Akron OH. 聽聽聽聽聽聽聽聽
- Advisor: Sailaja Paruchuri, Ph.D.
- 2015-2016
- Research Fellow, Indian Institute of Chemical Technology, Hyderabad, India. Advisor: Manika Pal Bhadra, Ph.D.
- 2008-2009
- Ad-hoc faculty for Organic Chemistry at Dept of Chemistry, Pratibha PG College, Osmania University, Hyderabad, India.
Awards & Commendations
- 2024: 鈥�Top 5 posters award鈥�, at Ohio Physiological Society (OPS) annual meeting- held at Ohio Medical University, Athens, OH.
- 2023: Chair鈥檚 Award for Excellence in Publications -2022, Department of Physiology and Pharmacology, University of Toledo, Toledo, OH
- 2021: Best Oral Presentation Award (3rd) in ASIOA - annual meeting-2021 virtual meeting
- 2019: 鈥�Gopal Krishna Memorial Junior Scientist Award in Biochemistry-2019鈥�, at Association of Scientists of Indian Origin in America (ASIOA), at Orlando, FL
- 2017: Best poster award in Ohio Physiological Society (OPS) annual meeting-2017 held at Northeast Ohio Medical University Rootstown, OH
- 2016: Nominated for TAS-Young Scientist Award 2016 (Telangana Academy of Sciences)
- 2015: Best Poster Award (2nd) in International Conference on Chemical Biology (ICCB) 2014, Hyderabad, India.
- 2013: 鈥�Award for Academic excellence鈥� from Indo-Global Education Summit-2013, by聽聽 Indus Foundation.
- 2013: International travel grant from the Department of Science and Technology-India (DST) & Department of Biotechnology (not availed) for participating in 3rd聽Nano Today conference held in Biopolis, Singapore.
- 2011: Senior research fellowship award from University Grants Commission, Govt. of India, India.
- 2009: Junior research fellowship award from University Grants Commission, Govt. of India, India.
- 2003: 鈥淟ouis Pasteur Gold Medal鈥� from Osmania University for best performance in undergraduate studies.
Selected Publications
- Teegala LR#, Gudneppanavar R#, Kattuman E#, Snyderman M, AV T, Thodeti CK and Paruchuri S. Prostaglandin E2 attenuates lung fibroblast differentiation via inactivation of Yes Associated Protein Signaling. FASEB J, 2023;37(10): e23199 (#Equal first authors).
- Gudneppanavar R#, Kattuman E#, Teegala LR#, Erik Southard, Thodeti CK and Paruchuri S. Epigenetic histone modification by butyrate downregulates KIT and attenuates mast cell function. J Cell Mol Med.聽2023; 00: 1鈥�12 (#Equal first authors).
- Teegala LR, Elshoweikh Y, Gudneppanavar R, Thodeti S, Pokhrel S, Southard E, Thodeti CK, & Paruchuri S. Protein Kinase C alpha and beta compensate for each other to promote stem cell factor-mediated KIT phosphorylation, mast cell viability and proliferation. FASEB J, 2022, 36(5).
- Pokhrel S, Gudneppanavar R, Teegala LR, Duah E, Thodeti CK and Paruchuri S. Leukotriene D4 Upregulates Oxidized Low-Density Lipoprotein Receptor 1 and CD36 to Enhance Oxidized LDL Uptake and Phagocytosis in Macrophages Through Cysteinyl Leukotriene Receptor 1. Frontiers in Physiology. 2021, 12:
- Al-Azzam N, Teegala LR, Pokhrel S, Ghebreigziabher S, Chachkovskyy T, Thodeti S, Gavilanes I, Covington K, Thodeti CK and Paruchuri S. Transient Receptor Potential Vanilloid channel regulates fibroblast differentiation and airway remodeling by modulating redox signals through NADPH Oxidase 4. Sci Rep. 2020, 10(1):9827.
- Teegala LR#, Duah E#, Kondeti V,聽Adapala RK, Keshamouni VG, Kanaoka Y, Austen KF, Thodeti CK and Paruchuri S. Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis. Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):199-204 (#Equal first authors).
- Teegala LR, Garikapati KR, Reddy SG, Reddy B V, Yadav JS, Bhadra U and Bhadra MP. 2016. Simultaneous delivery of Paclitaxel and Bcl-2 siRNA via pH-Sensitive liposomal nanocarrier for the synergistic treatment of melanoma. Sci Rep. 2016, 6: 35223.
- Rana S, Datta K, Teegala LR, Chatterjee E, Sen P, Pal-Bhadra M, Bhadra U, Pramanik A, Pramanik P, Chawla-Sarkar M, Sarkar S. A spatio-temporal cardiomyocyte targeted vector system for efficient delivery of therapeutic payloads to regress cardiac hypertrophy abating bystander effect. J Control Release. 2015, 200: 167-78.
- Teegala LR, Krishnarao PS, Rao GK, Bhimireddy E, Venkateswarlu P, Mohapatra DK, Yadav JS, Bhadra U and Bhadra MP. Para amino benzoic acid-derived self-assembled biocompatible nanoparticles for efficient delivery of siRNA. Int J Nanomedicine. 2015, 10: 6411-24.