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Department of Physiology and Pharmacology

Charles Thodeti, Ph.D., FAHA, FCVS

Charles ThodetiProfessor

Phone: 419.383.4253
Email: charles.thodeti@utoledo.edu

Laboratory of Cardiovascular Mechanobiology and Therapeutics听

ACADEMIC TITLE(S)

  • Professor of Physiology and Pharmacology

BIO

Dr. Charles Thodeti is a Professor in the Department of Physiology and Pharmacology at the University of Toledo. He obtained Ph.D. in Zoology from S.V. University, India. He did post-doctoral training at Lund University, Sweden and later held a research faculty position at the University of Copenhagen, Denmark. He then moved to Harvard Medical School/Boston Children鈥檚 Hospital as an Instructor/Staff Scientist. Before joining University of Toledo, Dr. Thodeti was a tenured Associate professor at Northeast Ohio Medical University (NEOMED). His laboratory (laboratory of Cardiovascular Mechanobiology and Therapeutics) works on mechanotransduction mechanisms in cardiac remodeling and pathological angiogenesis. His work has been supported by NIH-NHLBI (RO1s and R15), NIH-NCI-(R15) and AHA (Scientist Development Award, Grant-in-Aid and Transformative Project Award). He has published more than 60 peer-reviewed articles in the fields of cardiovascular physiology and cell biology. He serve(d)s as an editorial board member for Circulation Research, Scientific Reports, Microcirculation and Cells (MDPI), and as a reviewer for more than 30 top-tier journals. Dr. Thodeti is a study section member for AHA and NIH.

AREA OF EXPERTISE/RESEARCH INTERESTS

  • Mechanical signaling in Vascular Growth (Coronary, Tumor and Retinal Angiogenesis)
  • Mechanotransduction mechanism in cardiac fibroblast differentiation and cardiac remodeling
  • Extracellular Matrix, Integrin and RhoGTPases in cell adhesion, migration and differentiation
  • Ion (TRPV) channel function in the regulation of vascular tone
  • Eicosanoid signaling in cancer and inflammation

HONORS/AWARDS/FELLOWSHIPS

  • President, ASIOA (Association of Scientists of Indian Origin in America) 2020-present
  • Chair, Organizing Committee, ASIOA Annual (Virtual National) Conference, Jan 16-17, 2021
  • NEOMED Outstanding Faculty Research Award-2019:听 2020
  • Editorial Board Member of Cells: 2020-present
  • Editorial Board Member of Microcirculation: 2020-present
  • Mario Toppo Distinguished Scientist Award-2018; ASIOA
  • Chair-APS-CV section Fellowship (FAPS-FCVS) Committee, 2018-2021
  • Chair/Organizer: Featured topic-EB-2018
  • Chair/Organizer: Session-WCM-2018
  • Fellow of American Heart Association (FAHA)
  • NEOMED Junior Faculty Award 2015
  • Fellow of American Physiological Society-Cardiovascular Section (FAPS-FCVS)
  • Editorial Board Member of Circulation Research: 2015-2020 June
  • Editorial Board Member of Scientific Reports (Nature Publishing): 2016-present
  • Chair & Session Builder (Session on Angiogenesis) AHA scientific meeting-2012
  • AHA-Scientist Development Grant: 2006-2009
  • Post-doctoral Fellowship-Wenner-Gren Foundation, Stockholm, Sweden
  • Post-doctoral Fellowship-Swedish Institute, Stockholm, Sweden
  • Research Associate- Indian Council of Medical Research, New Delhi, India

听PROFESSIONAL MEMBERSHIPS

  • American Heart Association (AHA)
  • American Physiological Society (APS)
  • North American Vascular Biology Organization (NAVBO)
  • Microcirculatory Society (MCS)

FUNDING

Active Support:

听1) 1R01HL148585-01- Charles Thodeti (PI) 09/19/2019 鈥� 08/31/2023

Title:听听 Mechanical Control of Coronary Angiogenesis in Myocardial Adaptation to

Ischemia

Role: Principal Investigator (PI)

The goal of this proposal is to investigate the role of endothelial mechanical signaling in coronary angiogenesis.

听

Recently Completed Support:

听2) 1R01HL119705-01 Charles Thodeti (PI) 08/15/2015 鈥� 02/28/2021

Title:听 Mechanotransduction in Myocardial Adaptation to Ischemia

Role: Principal Investigator (PI)

The goal of this proposal is to investigate the role of mechanical signaling in the regulation of cardiac remodeling following myocardial infarction.听

3) 1R15CA202847-01 Charles Thodeti (PI) 12/01/2015 鈥� 05/31/2020

Title: Integration of Mechanical and Soluble Signaling in Tumor Angiogenesis

Role: Principal Investigator (PI) (Total budget: $453,140.00)

The goal of this project is to understand mechanotransduction mechanisms in tumor angiogenesis and develop novel mechanotransduction based vascular normalization (anti-angiogenic) therapies for the treatment of cancer.

听

DISTINCTIONS

  • President, ASIOA (Association of Scientists of Indian Origin in America) 2020-2022
  • Chair-APS-CV section Fellowship (FAPS-FCVS) Committee, 2018-2021
  • Chair-APS-Postdoctoral Fellowship CV section Subcommitte;2021-present
  • Member-APS-CV section Steering Committee, 2018-present
  • Member-Membership Committee-Microcirculatory Society
  • Editorial Board Member: Circulation Research, Scientific Reports, Microcirculation, Cells

PUBLICATIONS听

Peer Reviewed Publications (in reverse chronological order; Total: 67):

(Google Scholar- h index: 32; i10 index: 48; Total Citations: 3411)

  1. Adapala, R.K., Kanugula, A.K., Ohanyan, V., Paruchuri, S., Chilian, W.M. and Thodeti, C.K. (2021) TRPV4 deletion in endothelium protects heart against pressure overload induced hypertrophy (In submission)
  2. Paek, J., Teegala, L.R., Alisafaei, F., Clair, G.C., Song, J.W., Park, S.E., Ansong, C.K., Mondrinos, M.J., Shenoy, V., Thodeti, C.K., Paruchuri, S., and Huh, D. (2021) Mechanically actuatable airway disease-on-a-chip: a novel platform to study biomechanical basis of obstructive human lung disease (In preparation for Nat Biotechnology)
  3. Guarino, B., Bhavnani,N.,听 Adapala, R.K., Katari,V., Dougherty, J., Khan, M., Paruchuri, S., and Thodeti, C.K. (2021) Tumor-derived extracellular vesicles induce abnormal angiogenesis via TRPV4 downregulation and subsequent activation of Rho/YAP/VEGFR2 pathway (In Review: Cells).
  4. Yasmine, E., Teegala, L.R., Ravindra, G., Thodeti, S., Pokhrel, S., Thodeti, C.K. and Paruchuri, S. (2021) Protein Kinase C 伪 and 尾 compensate each other to promote stem cell factor-mediated c-kit phosphorylation, mast cell survival and proliferation. (In Review: J Cell Physiol).
  5. Pokhrel, S., Gudneppanavar, R., Teegala, L.R., Duah, E., Thodeti, C.K. and Paruchuri, S. (2021) Leukotriene D4 upregulates oxidized low-density lipoprotein receptor 1 and CD36 to enhance oxidized LDL uptake and phagocytosis in macrophages through Cysteinyl leukotriene receptor 1. (In Review: Frontier Physiol)
  6. Kanugula. A.K., Adapala, R.K., Jamaiyar, A., Lenkey, N., R, Guarino, B., Liedtke, W., Yin, L., Paruchuri, S. and Thodeti, C.K. (2021) Endothelial TRPV4 channel deletion promotes tumor growth and metastasisAngiogenesis doi: 10.1007/s10456-021-09775-9.)
  7. Cappelli, H., Guarino, B., Kanugula, A.K., Adapala, R.K., Perera, V., Smith, M., Paruchuri, S and Thodeti, C.K. (2020) Transient receptor potential vanilloid 4 channel deletion regulates pathological but not physiological retinal angiogenesis. J Cell Physiol Oct 20. doi: 10.1002/jcp.30116.
  8. Guarino, B., Paruchuri, S and Thodeti, C.K. (2020) Role of Transient receptor potential vanilloid 4 channels in ocular function. 听Exp. Eye Res. 201:108257.
  9. Adapala, R., Kanugula.A, Paruchuri, S., Chilian, W.M.and Thodeti, C.K. (2020) TRPV4 deletion protects heart from myocardial infarction-induced adverse remodeling via modulation of cardiac fibroblast differentiation Basic Res Cardiol 115(2):14. doi: 10.1007/s00395-020-0775-5.
  10. Al-Azzam, N., Teegala, L.R., Pokhrel, S., Ghebreigziabher, S., Chachkovskyy, T., Thodeti, S., Gavilanes, I., Covington, K., Thodeti, C.K. and Paruchuri, S (2020) Transient Receptor Potential Vanilloid channel regulates fibroblast differentiation and airway remodeling by modulating redox signals through NADPH Oxidase 4. Scientific Reports 10(1):9827.
  11. Guarino, B., Adapala, R.K.., Kanugula. A.K., Lenkey, N., Dougherty, J.A.,Paruchuri, S., Khan, M.and Thodeti, C.K. (2019) Extracellular vesicles from pathological microenvironment induce endothelial cell transformation and abnormal angiogenesis via modulation of TRPV4 channels (In review Front Cell Dev Biol 7:344. doi: 10.3389/fcell.2019.00344.
  12. Duah, E., Teegala, L.R., Kondeti, V., Adapala, R., Keshamouni, V., Kanaoka, Y., Austen, K.F., Thodeti, C.K. and Paruchuri, S (2019) Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis and metastasis. Proc Natl Acad Sci, USA116(1):199-204.
  13. Cappelli, H.C., Kanugula, A.K., Adapala, R.K., Amin, V., Sharma, P., Paruchuri, S., and Thodeti, C.K. (2019)Mechanosensitive TRPV4 channels regulate tumor vascular integrity and metastasis through stabilization of VE-cadherin junctions. Cancer Lett 442:15-20.
  14. Kanugula, A., Adapala, R., Midha, P., Cappelli, H., Meszaros, J.G., Paruchuri, S., Chilian, W.M. and Thodeti, C.K (2019). Novel non-canonical regulation of soluble VEGF/VEGFR2 signaling by mechanosensitive ion channel TRPV4. FASEB J 33(1):195-203. doi: 10.1096/fj.201800509R. [Epub ahead of print]
  15. Paruchuri, S. and Thodeti, C.K. (2018) Form follows function: Polymorphisms in mAKAP alter cardiac cAMP/PKA signalling. Am J Physiol Heart Circ Physiol 315(3):H626-H628. doi: 10.1152/ajpheart.00248.2018. Epub 2018 May 4.
  16. Kanugula, A.K. and Thodeti, C.K. (2018) AMP-activated kinase 鈥淜eaps鈥� ischemia/reperfusion-induced necroptosis under control. International Journal of Cardiology 259:168-169.
  17. Thodeti, C.K. (2017) Changing the Channels: Nature鈥檚 remote Controlling in Health and Disease. Circ Res 120(4):599-601.
  18. Gombedza, F., Kondeti, V., Al-Azzam, N.,听 Koppes, S., 听听Duah, E., Patil, P., Hexter, M., Phillips. D., Thodeti, C.K. and Paruchuri, S. (2017) Mechanosensitive transient receptor potential vanilloid4 regulates Dematophagoides farina-induced airway remodeling via two distinct pathways modulating matrix synthesis and degradation FASEB J. doi: 10.1096/fj.201601045R. [Epub ahead of print]
  19. DelloStritto, D.j., 听Sinharoy P., , Connell, P.J., 听Fahmy, J.N., Cappelli, H.C., 听Thodeti, C.K., 听Geldenhuys, W.J., 听Damron , D.S., and Bratz, I.N. (2016) 4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling. Free Radical Biol Med. 101:10-19.
  20. Thoppil, R., Cappelli, H., Adapala, R., Kanugula, A.K., Paruchuri, S. and Thodeti, C.K. (2016) TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway. Oncotarget. 7(18):25849-61
  21. , , , , , , 1, , , , (2016). Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction. 111(2):21.
  22. Adapala, R., Thoppil, R., Ghosh, K., Cappelli, H., Dudley, A.C., Paruchuri, S., Keshamouni, V., Klagsbrun, M., Meszaros, J.G., Chilian, W.M., Ingber, D. and Thodeti, C.K. (2016) Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy.听 Oncogene. 35(3):314-22.
  23. Kondeti, V., Al-Azzam, N.,听 Duah, E., Thodeti, C.K.,Boyce, J., and Paruchuri, S. (2016) Leukotriene D4 and Prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner via CysLT1R and EP3 receptors. Journal of Allergy and Clinical Immunology.137(1):289-98.
  24. Thoppil, R., Adapala, R., Cappelli, H., Kondeti, V.,Dudley, A.C., Meszaros, J.G., Paruchuri, S. and Thodeti, C.K. (2015) TRPV4 Channel activation selectively inhibits tumor endothelial cell proliferation. Scientific Reports (Nature Publishing Group). 5: 14257.
  25. 25.听 Thodeti, C.K*. (2015) A bouquet for a broken heart: can flowers repair a damaged heart? Circ. Res. 116(11):1729-31. doi: .1161/CIRCRESAHA.115.306590
  26. Al-Azzam, N., Kondeti, V., Duah, E., Gombedza, F., Thodeti, C.K.,and Paruchuri, S. (2015) Modulation of mast cell proliferative and inflammatory responses by Leukotriene D4 and Stem Cell Factor interactions. J. Cell. Physiol. 230(3):595-602
  27. Rahaman So, Grove LM, Paruchuri S, Southern BD, Abraham S, Niese KA, Scheraga RG, GHOSH S, Thodeti CK, Zhang DX, Moran MM, Schilling WP, Tschumperlin DJ, Olman MA.听听(2014). TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice. J Clin Invest.听124(12):5225-38.
  28. Shamhart, P.E., Luther, D.J., Adapala, R.K., Bryant, J.E., Petersen, K.A., Meszaros, J.G. and Thodeti, C.K. (2014) Hyperglycemia enhances function and differentiation of adult rat cardiac fibroblasts. Canadian J. Physiol. Pharmacol. 92(7):598-604.
  29. , , , , , and . (2013) Cysteinyl leukotrienes regulate endothelial cell inflammatory and proliferative signals through CysLT鈧� and CysLT鈧� receptors. (Nature Publishing Group) 3:3274.
  30. Luther, D.J., Thodeti, C.K., and Meszaros, J.G. (2013) Injury models to study cardiac remodeling in the mouse: myocardial infarction and ischemia-reperfusion. Methods Mol Biol. 1037:325-42.
  31. Kondeti, V., Duah, E.,听 Al-Azzam, N.,听 Thodeti, C.K.,听 Boyce, J.A. 听and Paruchuri, S. (2013) Differential regulation of cysteinyl leukotriene receptor signaling by protein kinase C in human mast cells. PLOS One. 8(8):e71536.
  32. Thodeti, C.K., Paruchuri, S., and Meszaros, J.G. (2013) A TRP to cardiac fibroblast differentiation. Channels.7: 211-214.
  33. Adapala, R., Thoppil, R., Luther, D.J., Sailaja, P., Meszaros, J.G., Chilian, W.M., and Thodeti, C.K. (2012)TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals. J. Mol.Cell.Cardiol. 54:45-52.
  34. Jolanta, M.K., Carl, S., Thodeti, C., Adapala, R, Ananth, M., Alamgir, K. (2012) Engineering2.5D Constructs for Characterizing Phase Separated Polymer Blend Surface Morphology in Tissue Engineering Scaffolds.J. Biomed. Mat. Res: Part A doi: 10.1002/jbm.a.34439.
  35. Jones, T.J., Adapala, R.K., Geldenhuys, W.J., Bursley, C., AbouAlaiwi, W.A., Nauli., S.M. and Thodeti, C.K. (2012) Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of hsp27 dependent actin cytoskeletal organization. J. Cell. Physiol. 227(1):70-6.
  36. Luther D.J, Thodeti C.K,听Shamhart P.E, Adapala R.K, Hodnichak C, Weihrauch D, Bonaldo P, Chilian W.M, Meszaros J.G. Absence of type VI collagen paradoxically improves cardiac function, structure, and remodeling after myocardial infarction.Circ Res. 2012 MAR 16;110 (6):851-6. (COVER PAGE).
  37. Sero JE, Thodeti C.K., Mammoto A, Bakal C, Thomas S, Ingber DE. (2012) Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning. PLoS One 6(12):e28303.
  38. Guarini, G., Ohanyan, V.A., Kmetz, J.G.,听 DelloStritto, D.J., Thoppil, R.J., Thodeti, C.K., Meszaros, J.G.,听 Damron, D.S. and Bratz, I.N.(2012) Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: Role of nitric oxide and BK channels. Am J Physiol Heart Circ Physiol. 303(2):H216-23.
  39. Chavez, R.J., Haney, R.M., Cuadra, R.H., Ganguly, R., Adapala, R.K., Thodeti, C.K. and Raman, P. (2012) Upregulation of Thrombospondin-1 Expression by Leptin in Vascular Smooth Muscle Cells via JAK2 and MAPK-dependent pathways. Am. J. Physiol. Cell Physiol.303(2):C179-91.
  40. Adapala, R.K., Talasila, P.K., Bratz, I.N., Zhang, D.X., Suzuki, M., Meszaros., J.G. and Thodeti, C.K.(2011) PKCa mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells 听Am.J. Physiol. Heart听 Circ. Physiol 听301(3):H757-65.
  41. Ohanyan VA, Guarini G, Thodeti C.K, Talasila PK, Raman P, Haney R, Meszaros JG, Damron DS, Bratz IN (2011) Endothelin Mediated In Vivo Pressor Responses following TRPV1 Activation. Am.J. Physiol. Heart Circ. Physiol听 301(3):H1135-42.
  42. Benjamin D. Matthews, Thodeti, C.K., Jessica D. Tytell, Akiko Mammoto, Darryl R. Overbyand Donald E. Ingber (2010). Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta 1 integrins. Integrative Biology2: 235-242.
  43. Chancellor, T.J., Lee, J., Thodeti, C.K., and Lele, T.(2010) Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration and cyclic strain induced reorientation. Biophys. J. 99: 115鈥�123.
  44. Thodeti, C.K., Matthews, B., Ravi, A., Mamotto, A., Ghosh, K., and Bracha, A., Ingber, D.E. (2009) TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin to integrin signaling. Circ. Res. 104:1123-1130.
  45. Alenghat, F.J., Tytell, J., Thodeti, C.K., Derrien, A., and Ingber, D.E. (2009) Mechanical control of cAMP signaling through integrin-dependent activation of heterotrimeric G伪s protein in focal adhesions. J. Cell. Biochem. 106:529-38.
  46. Ghosh, K., Thodeti, C.K., Dudley, A.C., Mammoto, A., Klagsbrun, M., and Ingber, D.E. (2008) Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proc. Natl. Acad. Sci. USA听105: 11305-10.
  47. Lele, T., Thodeti, C.K., Pendse, J., and Ingber, D.E. (2008) Investigating complexity of protein-protein interactions in focal adhesions. Biochem. Biophys. Res. Commun.369:929-34.
  48. Xia, N., Thodeti, C.K.,听 Hunt, T.P., Xu, Q., Ho, M., Whitesides, G.M., Westervelt, R., and Ingber, D.E (2008) Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation. FASEB J.听 22: 1649-59.
  49. Lele, T., Thodeti, C.K., and Ingber, D.E. (2006) Force meets chemistry: analysis of mechanochemical conversion in focal adhesions using fluorescence recovery after photobleaching. J. Cell. Biochem. 97:1175-83. (Cover Page).
  50. Thodeti, C.K., Frohlich, C., Nielsen, C.K., Takada, Y.,听 Fassler, R.,听 Albrechtsen, R. and Wewer, U.M. (2005) ADAM12-mediated focal adhesion formation is differently regulated by 尾1 and 尾3 integrins. FEBS Lett. 579: 5589-95.
  51. Thodeti, C.K.,听 Frohlich, C.,听 Nielsen, C.K.,听 ., ., ., ., Albrechtsen, R., Couchman, J.R. and Wewer, U.M. (2005) Hierarchy of ADAM12 binding to integrins in tumor cells. Exp. Cell Res. 309:438-50.
  52. Sundberg, C*., Thodeti, C.K., Kvieborg, M., Larsson, C., Parker, P., Albrechtsen, R., and Wewer, U,M. (2004) Regulation of ADAM12 cell-surface expression by protein kinase C epsilon. J. Biol.Chem.听 279:51601-11.
  53. Thodeti, C.K., Albrechtsen, R., Grauslund, M., Asmar, M., Larsson, C., Takada, Y., Mercurio, A., Couchman, J.R., and Wewer, U.M. (2003) ADAM12/syndecan-4 signaling promotes beta1integrin-dependent cell spreading through PKC伪 and Rho. J. Biol.Chem.278:9576-9584.
  54. Kawaguchi, N., Sundberg,C., Kveiborg, M., Moghadaszadeh, B., Asmar, M., Dietrich N., Thodeti C.K, Nielsen, F.C., Moller, P., Mercurio, A.M., Albrechtsen, R., and Wewer,U.M.(2003) ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function.J.Cell Sci. 116: 3893-904.
  55. Thodeti, C.K., R. Massoumi ., L. Bindslev., and A. Sjolander. (2002) Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells. Biochem. J. 365:157-163.
  56. Thodeti, C.K., and Sj枚lander, A. (2002) Leukotriene D4-induced calcium signalling in human intestinal epithelial cells. 听Adv. Exp. Med. Biol.507: 187-191.
  57. Thodeti, C.K., Nielsen, C.K., Larsson, C., and Sj枚lander, A. (2001) The epsilon isoform of protein kinase C is involved in the regulation of the LTD4-induced calcium signal in human intestinal epithelial cells. Exp.Cell.Res.262: 95-103.
  58. Thodeti, C.K., Adolfsson, J., Juhas, M., and Sj枚lander, A. (2000) Leukotriene D4 triggers an association between G尾纬 subunits and phospholipase C-纬1 in intestinal epithelial cells. J.Biol.Chem. 275: 9849-9853.
  59. Srinivasa Reddy., P., Charles Kumar, T., Narasa Reddy, M., Sarada, Ch., and Reddanna, P. (2000) Differential formation of octadecadienoic acid and octadecatrienoic acid products in control and injured/infected potato tubers. Biochim.Biophys.Acta 1483: 294-300.
  60. Anuradha D., Reddy K.V., Charles Kumar, T., Neeraja S., Reddy P.R., and Reddanna P. (2000) Purification and characterization of rat testicular glutathione S-transferases: role in the synthesis of eicosanoids. Asian J.Androl. 2: 277-82.听 听 听听
  61. Gr枚nroos, E., Thodeti, C.K., and Sj枚lander, A. (1998) Leukotriene D4 induces a rapid increase in cAMP in human epithelial cells, INT 407: A potential role for this signal in the regulation of calcium influx through the plasma membrane. Cell Calcium24: 9-16.
  62. Veera Reddy, K., Charles Kumar, T., Prasad, M., and Reddanna, P. (1998) Pulmonary lipid peroxidation and antioxidant defenses during induced physical exercise: Role of Vitamin E and selenium. Nutrition14: 448-451.
  63. Charles Kumar, T., Veera Reddy, K., Anuradha, D., and Reddanna,P. (1997) Enhanced production of LTB4 and free radicals in rat lung by exhaustive physical exercise. Biochem.Mol.Biol.Intl. 41: 641-646.
  64. Ramakrishna, B., Veera Reddy, K., Charles Kumar, T., and Reddanna, P.(1996) Glutathione-S transferases and carcinogenesis. Indian J.Comp. Anim. Physiol.14: 12-20.
  65. Veera Reddy, K., Anuradha, D., Charles Kumar, T., and Reddanna, P (1995) Induction of Ya1 subunit of hepatic glutathione S-transferase in rats by exercise training. Arch.Biochem.Biophys. 323:6-10.
  66. Veera Reddy, K., Charles Kumar, T., Prasad, M., and Reddanna, P. (1992) Exercise-induced oxidant stress in the lung tissue: Role of dietary supplementation of vitamin E and selenium. Biochem.Intl. 26: 863-871.
  67. Charles Kumar, T., Veera Reddy K., Prasad, M., Thyagaraju, K., and Reddanna, P. (1992) Dietary supplementation of vitamin E protects heart tissue from exercise-induced oxidant stress. Mol.Cell.Biochem. 111:109-115.

Book Chapters (Total: 5)

1. Kanugula, A., Adapala, R, Guarino, B., Bhavnani, B., Dudipala, H., Paruchuri, S., and Thodeti, C.K.* (2020). Methods for Studying Angiogenesis using Matrigel In Vitro and In Vivo. Methods in Molecular Biology.Volume: Vascular Permeability: Methods and Protocols. (Eds: Binu Tharakan). Springer Publications. In Press.(Invited)* Corresponding author.

2. Cappelli, H.C., Thoppil, R., Adapala, R, Meszaros, J.G., Paruchuri, S., and Thodeti, C.K.* (2015). Role of mechanosensitive TRP channels in Abnormal Vasculature of Tumors. Ion Channels in Vascular Disease. (Eds: Levitan, Irena and Dopico, Alejandro). Springer Publications. In Press.(Invited)* Corresponding author.

3. Ghosh, K., Thodeti, C.K., and Ingber, D.E.(2012)听 Micromechanical Design Criteria for Tissue Engineering Biomaterials. Biomaterials. Sci. (Eds: Ratner, Hoffman, Schoen and Lemons) 1165-1176.听(Invited)

4. Thodeti, C.K., * and Ghosh, K. (2009) Biophysical mechanisms of cell migration and invasion in lung cancer metastasis.听 In: Lung Cancer Metastasis: Novel Biological Mechanisms and Impact on Clinical Practice (Eds: Arenberg, D., Kalemkerian, G., and Keshamouni, V.) Springer Publishers. Pages 93-110.听(Invited)听*Corresponding author

5. Matthews, B., Thodeti, C.K., and Ingber, D.E. (2007) Activation of Mechanosensitive Ion Channels by Forces Transmitted through Integrins and the Cytoskeleton.听 Current Topics in Membranes (Ed; Hamill., O.P.) 58: 59-85.听(Invited)

PATENTS

  1. Improving Efficacy of Cancer Therapy: Don Ingber and Charles Thodeti(NEOMED with Harvard Medical School/Children鈥檚 Hospital Boston, renewed July 14, 2015).
  2. Modulation of Angiogenesis via TRPV4: Don Ingber and Charles Thodeti(NEOMED with Harvard Medical School/Children鈥檚 Hospital Boston, renewed May 14, 2015).
  3. TRPV4 as a Therapeutic Target for Cardioprotection in IHD (Charles Thodeti,Filed June 25, 2015; renewed 2016; renewed 2018; Filed petition: 2020)听

MEDIA

  • http://thepulse.neomed.edu/news/charles-thodeti-elected-to-national-office/
  • http://thepulse.neomed.edu/news/neomed-represented-at-american-heart-association-conference/
  • http://thepulse.neomed.edu/news/san-diego-conferences-bring-recognition/
  • https://businessjournaldaily.com/neomed-researchers-work-to-plug-blood-vessel-leaks/
  • http://thepulse.neomed.edu/news/ohio-physiological-society-meeting-recognizes-neomed-graduate-student/
  • 听 (page 8-11)

听听LAB MEMBERS听

  1. Ravi K. Adapala, Ph.D. (AHA-Postdoctoral Fellow)
  2. Venkatesh Katari Ph.D. (Postdoctoral Fellow)

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